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無創肺功能研究系統

全身體積描記系統（Whole Body Plethysmograph System）用于動物在清醒、無束縛狀態下，測量動物的各項肺功能參數。該系統簡單、易用、快速、數據輸出量大的特點使其成為國外藥企研發機構喜愛的研究工具，主要用于哮喘等新藥研發過程中進行粗篩實驗。其指標參數能夠良好地反映動物對藥物產生的氣道高反應情況，適合于需要動物在*自然狀態下呼吸的研究以及長期跟蹤實驗。

每個體描箱都具備霧化攻擊、溫濕度補償接口，另外還具有供水接口和氣體采樣接口以適用于各種特殊需要的研究。

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies， CO2 levels， temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.

During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing， this pressure difference is directly proportional to the respiratory pattern of the subject， allowing the researcher to measure respiratory rate and tidal volume， in accordance with ICH S7 Guidelines.

The system is commonly used in airway hyper-reactivity studieswhere， in addition to changes in ventilatory parameters， valuable data can obtained

by quantifying changes in the shape of the respiratory waveform， e.g.， Penh. However， it should be noted that when bronchoconstriction is present，

the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.

Parameters Measured

· Breathing frequency

· Tidal volume (during normal breathing)

· Minute volume

· Penh (enhanced pause)

· Inspiration time

· Expiration time

· Peak inspiratory flow

· Peak expiratory flow

· Explanation and more parameters

Features

· Non-invasive

· Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein， Drorbaugh & Fenn)

· Real time environmental monitoring (atmospheric pressure， temperature， humidity)

· Subject is unrestrained and conscious

· No anaesthesia

· Range of species including guinea pigs， rats and mice

· Chronic and long term use

· Measurement during aerosol challenge

·Up to sixteen animals measured simultaneously

· Optional body temperature measurement through telemetry

Uses

· Airway hyper-reactivity models

· Late phase response studies

· Chronic studies

· Drug screening

· Toxicology

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