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生物傳感器用于實時監測動物腦內神經化學物質的濃度變化。根據檢測物質不同,可用于谷氨酸(Glutamate),葡萄糖(glucose),乳酸( lactate) and 乙醇(ethanol)。配合數據采集器和軟件,用于可用于記錄清醒活動狀態下,動物中樞神經系統神經化學物質的濃度變化。通常用于行為學和生理活動研究,是藥物篩選和神經藥理學研究的理想工具。
Biosensors monitor real-time changes in neurochemical concentrations. With Pinnacle's turn-key electronic and software systems, users can record and analyze second-by-second concentration changes (not basal level) of CNS neurochemicals in freely moving animals . Biosensors are commonly used for in vivo monitoring during behavioral and physiological activities. They are also ideal for drug screening and investigating the neuropharmacological effects of different compounds.
Pinnacle offers glutamate,glucose,lactateand ethanol biosensors.
All biosensors sold by Pinnacle are for non-human use only.
In VivoLifetime | Limit of Detection | |
GLUTAMATE | 36 hours | 0.05 - 0.1 uM |
GLUCOSE | 96+ hours | 2 - 5 uM |
CGMS GLUCOSE | 17+ days | 25 - 50 uM |
LACTATE | 96+ hours | 5 - 10 uM |
ETHANOL | 6 - 8 hours | 0.1 - 0.5 uM |
BIOSENSOR DIAGRAM
Pinnacle biosensors function by the enzyme-mediated processing of the analyte of interest. This results in the production of hydrogen peroxide that is then detected by oxidation at a Pt-Ir electrode. Electroactive interferents present in the brain are excluded via a passive selective membrane and through active removal when necessary.
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